yes, its whistling because there is a little hole in the gasket and air is being sucked in.... giving that whistling sound.
The oxygen sensors are telling the computer that the engine is not getting enough gasoline (because of the extra unmetered air beign sucked in) and so gives an error code for a lean mixture.
Not really a misfire, but a lean code would pop up. I spose you could get a misfire code if it ran with a bad gasket long enough, since the computer is dumping in extra gasoline from the lean reading.
Isuzu mechanics can fix the gasket in around 30 minutes. Theyve done it a Zillion times.